Efficient scheduling of batch processes in continuous processing lines

This thesis focuses mainly on the development of efficient formulations for scheduling in industrial environments. Likewise, decisions over the processes more related to advanced process control or production planning are included in the scheduling; in this way, the schedule obtained will be more efficient than it would be if the additional restrictions were not considered. The formulations have to emphasize obtaining online implementations, as they are planned to be used in real plants. The most common scheduling problems handled in the industrial environments are: the assignment of tasks to units, the distribution of production among parallel units and the distribution of shared resources among concurrent processes. Most advances in this work are the result of a collaborative work.Departamento de Ingeniería de Sistemas y AutomáticaDoctorado en Ingeniería Industria

Slots Startup Synchronization with Shared Resources Dependency

Producción CientíficaIn this work the authors present a new formulation that allows an optimal schedule of batch processes with length dependence on the synchronization of the startup of the processes. It is also keep into account the distribution of shared resources among the devices.European Union, Horizon 2020 research and innovation programme under grant agreement No 723575 (CoPro)MINECO-FEDER (DPI2015-70975-P

Robust integrated production-maintenance scheduling for an evaporation network

Producción CientíficaThis work aims to reduce the global resource consumption in an industrial evaporation network by better tasks management and coordination. The network works in continuous, processing some products in several evaporation plants, so optimal load allocation and product-plant assignment problems appear. The plants have different features (capacity, equipment, etc.) and their performance is affected by fouling inside the heat exchangers and external factors. Hereby, the optimizer has to decide when maintenance operations have to be triggered. Therefore, a mixed production/maintenance scheduling problem arises. The plant behavior is approximated by surrogate linear models obtained experimentally, allowing thus the use of mixed-integer linear optimization routines to obtain solutions in acceptable time. Furthermore, uncertainty in the weather forecast and in the production plan is also considered via a two-stage stochastic programming approach. Finally, a trade-off analysis between other objectives of interest is given to support the decision maker.Spanish Government with project INOPTCON (MINECO/FEDER DPI2015-70975-P)

Optimization of crude oil operations scheduling by applying a two-stage stochastic programming approach with risk management

Producción CientíficaThis paper focuses on the problem of crude oil operations scheduling carried out in a system composed of a refinery and a marine terminal, considering uncertainty in the arrival date of the ships that supply the crudes. To tackle this problem, we develop a two-stage stochastic mixed-integer nonlinear programming (MINLP) model based on continuous-time representation. Furthermore, we extend the proposed model to include risk management by considering the Conditional Value-at-Risk (CVaR) measure as the objective function, and we analyze the solutions obtained for different risk levels. Finally, to evaluate the solution obtained, we calculate the Expected Value of Perfect Information (EVPI) and the Value of the Stochastic Solution (VSS) to assess whether two-stage stochastic programming model offers any advantage over simpler deterministic approaches.Gobierno de España - proyects a-CIDiT (PID2021-123654OB-C31) and InCo4In (PGC 2018-099312-B-C31)Junta de Castilla y León - EU-FEDER (CLU 2017-09, CL-EI-2021-07, UIC 233

XXXVIII Jornadas de Automática

Producción CientíficaThis work presents a decision-support tool to address the model-based optimization approach for online load allocation and scheduling of cleaning operations in an evaporation network. The aim is improving the resource efficiency by supplying the optimal solution for a given production goal. The approach includes the semi-automatic update of evaporator models, which is based on historical data for minimal modelling effort. The structure of the problem is formulated via mixed-integer programming and integrated into the plant supervision systems. Production constraints, concerns about the practical implementation and visualization preferences are also taken into account in the design of the prototypical tool.MINECO/FEDER Grant DPI2015-70975 (INOPTCON)EU H2020-SPIRE Grant Agreement nº 723575 (CoPro

Aproximación de modelos algebraicos mediante ALAMO y Ecosimpro

[Resumen] El diseño de modelos apropiados para la simulación es, normalmente, un proceso largo y tedioso; por ello, no es conveniente utilizar el mismo modelo detallado para control y optimización. En la mayoría de los casos, los modelos necesarios para la optimización pueden ser más sencillos siempre y cuando reproduzcan las características principales de los modelos complejos. En este trabajo se ha diseñado un sistema para obtener modelos algebraicos sencillos a partir de un modelado más complejo desarrollado para la simulación.Ministerio de Economía y Competitividad; DPI2015-70975-

Enriched mannose glycosylation contributes to Act d 2 allergenicity.

Allergens are responsible for the Th2 response in patients as part of complex mixtures of proteins, fatty acids and other molecules. Plant allergens have hitherto been included in several protein families that share no common biochemical features. Their physical, biochemical and immunological characteristics have been widely studied, but no definite conclusion has been reached about what makes a protein an allergen. N-glycosylation is characteristic of plant allergen sources but is not present in mammals

Resistance to 2-Hydroxy-Flutamide in Prostate Cancer Cells Is Associated with the Downregulation of Phosphatidylcholine Biosynthesis and Epigenetic Modifications

18 p.In this study, we examined the metabolic adaptations of a chemoresistant prostate cancer cell line in comparison to a sensitive cell line. We utilized prostate cancer LNCaP cells and subjected them to a stepwise increase in the antiandrogen 2-hydroxy-flutamide (FLU) concentration to generate a FLU-resistant cell line (LN-FLU). These LN-FLU cells displayed characteristics of cancer stem cells, exhibited drug resistance, and showed a significantly reduced expression of Cyclin D1, along with the overexpression of p16, pointing to a proliferation arrest. In comparing the cancer stem-like LN-FLU cells to the LNCaP cells, we observed a decrease in the expression of CTP-choline cytidylyl transferase ? (CCT?), as well as a decline in choline kinase, suggesting altogether a downregulation of the phosphatidylcholine biosynthetic pathway. In addition, we found decreased levels of the protein methyl transferase PRMT2 and the upregulation of the histone deacetylase Sirtuin1 (Sirt1). Analysis of the human prostate cancer samples revealed similar results in a population with high expressions of the stem cell markers Oct4 and ABCB1A1. Our findings suggest that the adaptation of prostate cancer cells to antiandrogens could induce reprogramming into stem cells that survive in a low phosphocholine metabolism and cell cycle arrest and display drug resistance.Instituto de Salud Carlos IIFundación Tatiana Pérez de Guzmán el BuenoComunidad de Madri

Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study.

The study of cross-reactivity in allergy is key to both understanding. the allergic response of many patients and providing them with a rational treatment In the present study, protein microarrays and a co-sensitization graph approach were used in conjunction with an allergen microarray immunoassay. This enabled us to include a wide number of proteins and a large number of patients, and to study sensitization profiles among members of the LTP family. Fourteen LTPs from the most frequent plant food-induced allergies in the geographical area studied were printed into a microarray specifically designed for this research. 212 patients with fruit allergy and 117 food-tolerant pollen allergic subjects were recruited from seven regions of Spain with different pollen profiles, and their sera were tested with allergen microarray. This approach has proven itself to be a good tool to study cross-reactivity between members of LTP family, and could become a useful strategy to analyze other families of allergens